Certain patients at risk for arrhythmias with azithromycin use, FDA warns

The U.S. Food and Drug Administration (FDA) is warning the public that azithromycin  can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart  rhythm. Patients at particular risk for developing this condition include those with known risk factors such as existing QT interval prolongation, low blood levels of potassium or magnesium, a slower than normal heart rate, or use of certain drugs used to treat arrhythmias. http://www.fda.gov/drugs/drugsafety/ucm341822.htm

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High-dose daptomycin in the treatment of infective endocarditis is succesfull

This was a multicentre, retrospective observational study (2005-11). Seventy patients met the inclusion criteria and comprised 33 (47.1%) with right-sided IE (RIE), 35 (50%) with left-sided IE (LIE) and 2 with both RIE and LIE. Sixty-five patients received daptomycin as salvage therapy. For those patients with pathogens isolated (n = 64), the organism was eradicated in 57 (89.1%) patients. Among 64 clinically evaluable patients, 55 (85.9%) achieved clinical success. No patients required discontinuation of high-dose daptomycin due to creatine phosphokinase elevations. http://jac.oxfordjournals.org/content/early/2013/08/07/jac.dkt294.full.pdf...

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U.S. Hospitalizations for Pneumonia after a Decade of Pneumococcal Vaccination

Background The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into the U.S. childhood immunization schedule in 2000 has substantially reduced the incidence of vaccine-serotype invasive pneumococcal disease in young children and in unvaccinated older children and adults. By 2004, hospitalizations associated with pneumonia from any cause had also declined markedly among young children. Because of concerns about increases in disease caused by nonvaccine serotypes, we wanted to determine whether the reduction in pneumonia-related hospitalizations among young children had been sustained...

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Salmonella Serovars Isolated in Turkey Up to the End of Year 2011

ABSTRACT Bacteria in Salmonella genus are separated into more than 2600 serovars. It is important that the isolated serovars and their sources are known in a certain country. This will help the identification of new Salmonella serovars that will be isolated later on. Since there is no Salmonella reference center in Turkey, Salmonella serovars isolated in Turkey were mainly reported by the articles of Aksoycan's manuscripts in various years, and in the list of Töreci and Anğ in 1991. The...

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Türkiyede hastane kökenli PVL üreten S.aureus yayılıyor..

Hastane ve toplum kökenli S.aureus suşlarında PVL varlığının saptanması ve PVL pozitif suşlar arasındaki klonal ilişkinin belirlenmesi amaçlandığı çalışmada çeşitli klinik örneklerden (yara, kan, trakeal aspirat,idrar, dren, kateter, parasentez sıvısı) izole edilen ve CDC kriterlerine göre tanımlanan 88 toplum kökenli ve 177 hastane kökenli olmak üzere toplam 265 S.aureus suşu dahil edilmiştir. S.aureus suşlarında metisilin direnci konvansiyonel yöntemlerle, PVL ve mecA gen bölgeleri polimeraz zincir reaksiyonu ile, PVL pozitif saptanan suşlar arasındaki klonal ilişki ise değişken alanlı jel elektroforezi (Pulsed...

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