High-dose daptomycin in the treatment of infective endocarditis is succesfull

This was a multicentre, retrospective observational study (2005-11). Seventy patients met the inclusion criteria and comprised 33 (47.1%) with right-sided IE (RIE), 35 (50%) with left-sided IE (LIE) and 2 with both RIE and LIE. Sixty-five patients received daptomycin as salvage therapy. For those patients with pathogens isolated (n = 64), the organism was eradicated in 57 (89.1%) patients. Among 64 clinically evaluable patients, 55 (85.9%) achieved clinical success. No patients required discontinuation of high-dose daptomycin due to creatine phosphokinase elevations.


Haber: Dr.Ümit Savaşçı

Posted September 9, 2013