New Developments

Having studied data from nearly 30,000 patients with a history of cardiac arrest, researchers conclude that over-the-counter NSAIDs should only be available in pharmacies and at low doses and quantities. Clinical Pharmacist29 MAR 2017   Source: Stephen Barnes / Alamy Stock Photo Research published in the European Heart Journal: Cardiovascular Pharmacotherapy showed that diclofenac was linked to a 50% increased risk of cardiac arrest while ibuprofen was linked to a 31% increase in risk. Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with...

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SAN FRANSISCO — Providers of inpatient care who have prescribing authority have a poor understanding of when to consult an allergist about penicillin allergies, according to results from a new survey. Despite acknowledging the need for allergy consultation in clinical scenarios, only 20% of respondents were able to judge when a patient would need a consultation with an allergist, and 42% did not know that penicillin allergy can resolve over time. Read more.. Ingrid Hein November 16, 2016

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An Assessment of Antibiotic Stewardship Interventions There is a consensus that antibiotic resistance has reached a crisis status requiring substantial response through two mechanisms: new antibiotic development and smart  antibiotic use. Physicians have minimal control over the development of new antibiotics, but near absolute control over how they are used. (A major exception is antibiotic use in agriculture.) There is general agreement that contemporary prescribing practice includes substantial misuse of antibiotics. It has been estimated that about 50% of antibiotic...

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R. Flisiak; E. Janczewska; M. Wawrzynowicz-Syczewska; J. Jaroszewicz; D. Zarezbska-Michaluk; K. Nazzal; B. Bolewska; J. Bialkowska; H. Berak; K. Fleischer-Stezpniewska; K. Tomasiewicz; K. Karwowska; K. Rostkowska; A. Piekarska; O. Tronina; G. Madej; A. Garlicki; M. Lucejko; A. Pisula; E. Karpińska; W. Kryczka; A. Wiercińska-Drapało; I. Mozer-Lisewska; M. Jabłkowski; A. Horban; B. Knysz; M. Tudrujek; W. Halota; K. Simon Disclosures Aliment Pharmacol Ther. 2016;44(9):946-956.  Abstract and Introduction Abstract Background Virologic and safety outcomes of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin (OBV/PTV/r ± DSV...

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Prevention of Progression to Cirrhosis in Hepatitis C With Fibrosis Effectiveness and Cost Effectiveness of Sequential Therapy With New Direct-acting Anti-virals http://www.medscape.com/viewarticle/869525?nlid=110509_804&src=WNL_mdplsfeat_161108_mscpedit_infd&uac=177387BK&spon=3&impID=1230660&faf=1 R. Faria; B. Woods; S. Griffin; S. Palmer; M. Sculpher; S. D. Ryder Disclosures Aliment Pharmacol Ther. 2016;44(8):866-876.  Aim To identify the cost-effective treatment for patients with HCV infection with F3 liver fibrosis who are at high risk of progression to cirrhosis.   Methods A decision-analytic Markov model compared the health benefits and costs of all currently licensed treatments...

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Medscape Medical News With the tuberculosis (TB) epidemic worse than previously thought, killing more people than HIV and malaria, ending it will take greater global action and investment, the World Health Organization (WHO) said in a report released today. The End TB Strategy, adopted by all WHO member states in 2014, aims to decrease TB incidence by 80% and reduce TB deaths by 90% by 2030. "We face an uphill battle to reach the global targets for tuberculosis," Margaret Chan,...

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Harini Sooryanarain, Subbiah Elankumaran Annual Review of Animal Biosciences 2015, 3: 347-73   The environmental drivers of influenza outbreaks are largely unknown. Despite more than 50 years of research, there are conflicting lines of evidence on the role of the environment in influenza A virus (IAV) survival, stability, and transmissibility. With the increasing and looming threat of pandemic influenza, it is important to understand these factors for early intervention and long-term control strategies. The factors that dictate the severity and...

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Mysterious New Mosquito-Borne Disease Found in Caribbean http://www.genengnews.com/gen-news-highlights/mysterious-new-mosquito-borne-disease-found-in-caribbean/81253208/ Physicians in Haiti and researchers from the University of Florida (UF) have stumbled upon a patient infected with a rare virus that until recently has been confined to small outbreaks in the Amazon. Known as Mayaro virus, this pathogen belongs to the Alphavirus genus, is closely related to chikungunya, and produces a dengue-like illness that is often accompanied by long-lasting arthralgia (joint pain). Whether this case signals the start of a new...

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