Major depressive disorder (MDD) is associated with poor virologic outcomes and faster HIV progression. Although persistent cerebrospinal fluid (CSF) HIV RNA is associated with MDD, it is unknown whether MDD is associated with detectable CSF virus when plasma virus is undetectable in persons taking antiretroviral drugs (CSF viral escape). MDD is associated with increased risk for CSF viral escape. Ongoing CSF viral replication may occur in more persons than previously estimated. Careful evaluation and treatment of depression may improve HIV control. Additional research is needed to continue to improve our understanding of mechanisms that may be responsible for the relationship between depression and HIV viral replication.
Haber: Dr. Sibel Bolukçu