{"id":740,"date":"2017-03-31T15:26:09","date_gmt":"2017-03-31T12:26:09","guid":{"rendered":"https:\/\/infeksiyon.org\/?p=740"},"modified":"2017-03-31T15:44:13","modified_gmt":"2017-03-31T12:44:13","slug":"diklofenak-ve-ibuprofen-kardiyak-arrest-riski-onemli-olcude-artti","status":"publish","type":"post","link":"https:\/\/infeksiyon.org\/en\/diklofenak-ve-ibuprofen-kardiyak-arrest-riski-onemli-olcude-artti\/","title":{"rendered":"Diclofenac and ibuprofen linked to significantly increased risk of cardiac arrest"},"content":{"rendered":"
\n
\n
\n
\n\t\t\t\tHaving studied data from nearly 30,000 patients with a history of cardiac arrest, researchers conclude that over-the-counter NSAIDs should only be available in pharmacies and at low doses and quantities.\n\t\t\t<\/div>\n
\n\t\t\t\tClinical Pharmacist<\/a><\/span>29 MAR 2017<\/span>\n\t\t\t<\/div>\n<\/p><\/div>\n
\n
\n
\n\t\t\t\t\t \n\t\t\t\t<\/div>\n
\n\t\t\t\t\tSource: Stephen Barnes \/ Alamy Stock Photo<\/cite>\n\t\t\t\t<\/div>\n
\n\t\t\t\t\tResearch published in the European Heart Journal: Cardiovascular Pharmacotherapy<\/em> showed that diclofenac was linked to a 50% increased risk of cardiac arrest while ibuprofen was linked to a 31% increase in risk.\n\t\t\t\t<\/div>\n<\/p><\/div>\n
\n\t\t\t\tNon-steroidal anti-inflammatory drugs (NSAIDs) have been associated with increased cardiovascular risk for the past ten years, but the link between NSAIDs and cardiac arrest specifically has not been examined.\n\t\t\t<\/div>\n
\n\t\t\t\tTo investigate, researchers used the Danish Cardiac Arrest Registry to identify 28,947 patients who had had an out-of-hospital cardiac arrest between 2001 and 2010. The data showed that 3,376 were treated with an NSAID up to 30 days before their cardiac arrest.\n\t\t\t<\/div>\n
\n\t\t\t\tThe results, published in the European Heart Journal: Cardiovascular Pharmacotherapy<\/em>[1]<\/a><\/sup> (2017;356:100-107), also showed that the NSAID diclofenac was linked to a 50% increased risk of cardiac arrest (odds ratio [OR] 1.50, 95% confidence interval [CI] 1.23­–1.82) while ibuprofen was linked to a 31% increase in risk (OR 1.31, 95% CI 1.14–1.51).\n\t\t\t<\/div>\n
\n\t\t\t\tThe researchers say that any conclusions on causality should be made with caution but recommend that over-the-counter NSAIDs should only be available at pharmacies, in limited quantities and at low doses.\n\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n

\n\tReferences:
\n<\/h3>\n
\n
\n
\n
\n
\n
\n\t\t\t\t\t\t[1]<\/a><\/sup>Sondergaard K, Weeke P, Wissenberg M et al<\/em>. Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Eur Heart J Cardiovasc Pharmacother<\/em> 2017;356:100-107. doi: 10.1093\/ehjcvp\/pvw041<\/a>\n\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n
\n
\n\t\t\t\tCitation: <\/strong>Clinical Pharmacist<\/span>, Vol 9, No 4, online | <\/span>DOI: 10.1211\/CP.2017.20202466<\/span>\n\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Having studied data from nearly 30,000 patients with a history of cardiac arrest, researchers conclude that over-the-counter NSAIDs should only be available in pharmacies and at low doses and quantities. Clinical Pharmacist29 MAR 2017   Source: Stephen Barnes \/ Alamy Stock Photo Research published in the European Heart Journal: Cardiovascular Pharmacotherapy showed that diclofenac was linked to… <\/p>\n","protected":false},"author":1,"featured_media":742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[9],"tags":[],"_links":{"self":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts\/740"}],"collection":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/comments?post=740"}],"version-history":[{"count":4,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts\/740\/revisions"}],"predecessor-version":[{"id":745,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts\/740\/revisions\/745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/media\/742"}],"wp:attachment":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/media?parent=740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/categories?post=740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/tags?post=740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}