{"id":480,"date":"2016-08-08T16:19:09","date_gmt":"2016-08-08T13:19:09","guid":{"rendered":"http:\/\/infeksiyon.org\/?p=480"},"modified":"2016-08-08T16:19:47","modified_gmt":"2016-08-08T13:19:47","slug":"tedavisi-zor-bakteriyel-infeksiyonlarla-mucadelede-yeni-bir-donem-yeniden-programlanan-e-coli","status":"publish","type":"post","link":"https:\/\/infeksiyon.org\/en\/tedavisi-zor-bakteriyel-infeksiyonlarla-mucadelede-yeni-bir-donem-yeniden-programlanan-e-coli\/","title":{"rendered":"Reprogrammed E. coli: A novel circuit  to combat hard-to-treat bacterial infections"},"content":{"rendered":"<p style=\"text-align: justify;\">Hwang et.all. demonstrate a novel genetic circuit that reprograms <em>Escherichia coli<\/em> to specifically recognize, migrate toward, and eradicate both dispersed and biofilm-encased pathogenic <em>Pseudomonas aeruginosa<\/em> cells. The reprogrammed <em>E. coli<\/em> degraded the mature biofilm matrix and killed the latent cells encapsulated within by expressing and secreting the antimicrobial peptide microcin S and the nuclease DNaseI upon the detection of quorum sensing molecules naturally secreted by <em>P. aeruginosa<\/em>. Hwang et.all. achieved signifincantly improved killing activity against planktonic and mature biofilm cells due to target localization, thus creating an active pathogen seeking killer <em>E. coli.<\/em><\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Reprogramming+microbes+to+be+a+pathogen-seeking+killer\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Reprogramming+microbes+to+be+a+pathogen-seeking+killer<\/a><\/p>\n<p style=\"text-align: justify;\"><strong>Dr. Yasemin \u00c7a\u011f<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Posted October 9, 2013<\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Hwang et.all. demonstrate a novel genetic circuit that reprograms Escherichia coli to specifically recognize, migrate toward, and eradicate both dispersed and biofilm-encased pathogenic Pseudomonas aeruginosa cells. The reprogrammed E. coli degraded the mature biofilm matrix and killed the latent cells encapsulated within by expressing and secreting the antimicrobial peptide microcin S and the nuclease DNaseI&#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[9],"tags":[],"_links":{"self":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts\/480"}],"collection":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/comments?post=480"}],"version-history":[{"count":1,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts\/480\/revisions"}],"predecessor-version":[{"id":481,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/posts\/480\/revisions\/481"}],"wp:attachment":[{"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/media?parent=480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/categories?post=480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infeksiyon.org\/en\/wp-json\/wp\/v2\/tags?post=480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}